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由康卡纳林注射到乳原区引起的水性干眼病的兔子模型：药物功效研究的应用
JoVE Journal
Medicine
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JoVE Journal Medicine
A Rabbit Model of Aqueous-Deficient Dry Eye Disease Induced by Concanavalin A Injection into the Lacrimal Glands: Application to Drug Efficacy Studies
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由康卡纳林注射到乳原区引起的水性干眼病的兔子模型：药物功效研究的应用

English

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11,801 Views

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08:04 min

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January 24, 2020

DOI:

10.3791/59631-v

DOI:
10.3791/59631-v

•

08:04 min
January 24, 2020

•

24 Views
, ,
1Department of Ophthalmology,Stony Brook University, 2Department of Preventive Medicine,Stony Brook University, 3Medicon Pharmaceuticals, Inc.

Summary

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本文介绍了一种方法，通过注射结沙蛋白A到轨道乳腺系统的所有部分来诱发兔子急性或慢性干眼病。该方法优于已经报告的方法，产生了一种可重复的、稳定的干眼模型，适合药理剂的研究。

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Honkanen, R. A., Huang, L., Rigas, B. A Rabbit Model of Aqueous-Deficient Dry Eye Disease Induced by Concanavalin A Injection into the Lacrimal Glands: Application to Drug Efficacy Studies. J. Vis. Exp. (155), e59631, doi:10.3791/59631 (2020).

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