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Evaluation of Keratinocyte Proliferation on Two- and Three-dimensional Type I Collagen Substrates
JoVE Journal
Bioengineering
This content is Free Access.
JoVE Journal Bioengineering
Evaluation of Keratinocyte Proliferation on Two- and Three-dimensional Type I Collagen Substrates

Evaluation of Keratinocyte Proliferation on Two- and Three-dimensional Type I Collagen Substrates

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08:19 min

April 22, 2019

DOI:

08:19 min
April 22, 2019

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Summary

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Here, we present a protocol for the preparation of two different forms of culture substrates utilizing type I collagen. Depending on how collagen is handled, collagen molecules either maintain two-dimensional, non-fibrous form or reassemble into three-dimensional, fibril form. Cell proliferation on type I collagen is drastically affected by fibril formation.

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