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Electrophoretic Delivery of γ-aminobutyric Acid (GABA) into Epileptic Focus Prevents Seizures in Mice
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May 16, 2019
DOI:
1Aix Marseille Université, Institut de Neurosciences des Systèmes (INS), 2Electrical Engineering Division,University of Cambridge, 3Department of Bioelectronics,Centre Microélectronique de Provence – Ecole Nationale Supérieure des Mines de Saint-Étienne (CMP-EMSE), 4Institut de Neurosciences de la Timone,Centre National de la Recherche Scientifique (CNRS) UMR 7289 & Aix- Marseille Université, 5Neuroengineering Research Group, Interdisciplinary Excellence Center, Department of Medical Microbiology and Immunobiology,University of Szeged
Summary
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The challenge of epilepsy research is to develop novel treatments for patients where classical therapy is inadequate. Using a new protocol—with the help of an implantable drug delivery system—we are able to control seizures in anesthetized mice by the electrophoretic delivery of GABA into the epileptic focus.
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Slezia, A., Proctor, C. M., Kaszas, A., Malliaras, G. G., Williamson, A. Electrophoretic Delivery of γ-aminobutyric Acid (GABA) into Epileptic Focus Prevents Seizures in Mice. J. Vis. Exp. (147), e59268, doi:10.3791/59268 (2019).
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