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Use of In Vivo Single-fiber Recording and Intact Dorsal Root Ganglion with Attached Sciatic Nerve to Examine the Mechanism of Conduction Failure
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August 27, 2019
DOI:
1Department of Neurobiology, School of Basic Medicine,Fourth Military Medical University, 2Department of Toxicology, School of Public Health,ShanXi Medical University, 3Department of Psychology,Fourth Military Medical University, 4Department of Neurobiology, School of Basic Medical Sciences, Advanced Innovation Center for Human Brain Protection,Capital Medical University, 5Neuroscience Research Institute, Key Lab for Neuroscience, Ministry of Education/National Health Commission,Peking University, 6Department of Radiation Biology, Faculty of Preventive Medicine,Fourth Military Medical University
Summary
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Single-fiber recording is an effective electrophysiological technique that is applicable to the central and peripheral nervous systems. Along with the preparation of intact DRG with the attached sciatic nerve, the mechanism of conduction failure is examined. Both protocols improve the understanding of the peripheral nervous system's relationship with pain.
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Mao, H., Wang, X., Chen, W., Liu, F., Wan, Y., Hu, S., Xing, J. Use of In Vivo Single-fiber Recording and Intact Dorsal Root Ganglion with Attached Sciatic Nerve to Examine the Mechanism of Conduction Failure. J. Vis. Exp. (150), e59234, doi:10.3791/59234 (2019).
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