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诱导BALB/c小鼠药物诱导的自身免疫性肝炎研究其致病机制
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Immunology and Infection
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JoVE Journal Immunology and Infection
Induction of Drug-Induced, Autoimmune Hepatitis in BALB/c Mice for the Study of Its Pathogenic Mechanisms
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诱导BALB/c小鼠药物诱导的自身免疫性肝炎研究其致病机制

English

Automatically Generated

2,757 Views

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11:36 min

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May 29, 2020

DOI:

10.3791/59174-v

DOI:
10.3791/59174-v

•

11:36 min
May 29, 2020

•

5 Views
, , , ,
1Department of Anesthesiology and Critical Care Medicine,Johns Hopkins University, 2Department of Pediatrics and Pathology,Johns Hopkins University

Summary

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我们描述了BALB / c小鼠中的体内免疫，转化性肝炎模型，可用于研究药物诱导的自身免疫性肝炎的发病机制，包括该疾病中看到的性别差异。我们将描述该模型如何使用体内和体外实验技术演示可重复的分析。

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Cite this Article

Thomas, D., Wu, T. Y., Cottagiri, M., Nyandjo, M., Njoku, D. B. Induction of Drug-Induced, Autoimmune Hepatitis in BALB/c Mice for the Study of Its Pathogenic Mechanisms. J. Vis. Exp. (159), e59174, doi:10.3791/59174 (2020).

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