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Efficace Construction d’échafaudages Drug-like Bispirocyclic Via Cycloadditions rapide de α-Imino γ-Lactones et alkylidène Hydantoïdes
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JoVE Journal Chemistry
Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
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Efficace Construction d’échafaudages Drug-like Bispirocyclic Via Cycloadditions rapide de α-Imino γ-Lactones et alkylidène Hydantoïdes

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6,742 Views

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10:17 min

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February 07, 2019

DOI:

10.3791/59155-v

DOI:
10.3791/59155-v

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10:17 min
February 07, 2019

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1School of Basic Medical Sciences,Lanzhou University, 2School of Pharmaceutical Sciences,Sun Yat-sen University

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Keyword Extraction:Drug-like Bispirocyclic ScaffoldsOrganocatalytic Cycloadditionsα-imino γ-lactonesAlkylidene PyrazolonesBipolar CycloadditionBispirocyclic CompoundsNatural ProductsBiological ActivitiesChiral Spiral CentersHigh YieldsStereoselectivityPyrazoloneHydrazineEthyl Acetoacetateα-arylidiene PyrazolinoneBenzaldehydeMagnesium OxideAcetonitrile

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Zhou, Y., Chen, N., Cheng, Y., Cai, X. Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones. J. Vis. Exp. (144), e59155, doi:10.3791/59155 (2019).

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