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A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease
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Immunology and Infection
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JoVE Journal Immunology and Infection
A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease

English

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6,374 Views

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04:23 min

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April 28, 2019

DOI:

10.3791/59132-v

DOI:
10.3791/59132-v

•

04:23 min
April 28, 2019

•

2 Views
, , , , , , ,
1Graduate Institute of Medical Sciences, College of Medicine,Taipei Medical University, 2Department of Microbiology and Immunology, School of Medicine, College of Medicine,Taipei Medical University, 3Center of Infectious Disease and Signaling Research,National Cheng Kung University

Summary

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Here, we present a protocol for creating an immunocompetent ICR (Institute of Cancer Research) murine model of central nervous system infection to display the development of neuropathy. Monitoring acute viral encephalitic disorders by identical disease scores could be performed for showing dengue virus-induced neuropathy in vivo.

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Shen, T., Jhan, M., Kao, J., Ho, M., Tsai, T., Tseng, P., Wang, Y., Lin, C. A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease. J. Vis. Exp. (146), e59132, doi:10.3791/59132 (2019).

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