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Immunology and Infection
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Immunization of Adult Zebrafish for the Preclinical Screening of DNA-based Vaccines
JoVE Journal
Immunology and Infection
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JoVE Journal Immunology and Infection
Immunization of Adult Zebrafish for the Preclinical Screening of DNA-based Vaccines

Immunization of Adult Zebrafish for the Preclinical Screening of DNA-based Vaccines

English

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11,530 Views

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05:39 min

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October 30, 2018

DOI:

10.3791/58453-v

DOI:
10.3791/58453-v

•

05:39 min
October 30, 2018

•

6 Views
, , ,
1BioMediTech Institute, Faculty of Medicine and Life Sciences,University of Tampere, 2MedEngine Oy, 3Department of Pediatrics,Tampere University Hospital, 4Department of Children and Adolescents,Oulu University Hospital, 5PEDEGO Research Unit, Medical Research Center,University of Oulu

Summary

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Here we describe a protocol for the immunization of the adult zebrafish (Danio rerio) with a DNA-based vaccine and demonstrate the validation of a successful vaccination event. This method is suitable for the preclinical screening of vaccine candidates in various infection models.

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Cite this Article

Myllymäki, H., Niskanen, M., Oksanen, K., Rämet, M. Immunization of Adult Zebrafish for the Preclinical Screening of DNA-based Vaccines. J. Vis. Exp. (140), e58453, doi:10.3791/58453 (2018).

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