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طراز ماوس تشيميريك كبد البشري الكوليستيرول أسرية باستخدام خلايا الكبد المستمدة من الخلايا الجذعية المستحثة Pluripotent
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September 15, 2018
DOI:
1Department of Medicine,University of Hong Kong-Shenzhen Hospital, 2The Cardiology Division, Department of Medicine, Li Ka Shing Faculty of Medicine,University of Hong Kong, 3School of Biomedical Sciences, Institute of Vascular Medicine, Li Ka Shing Institute of Health Sciences,Chinese University of Hong Kong, 4Key Laboratory of Regenerative Biology of the Chinese Academy of Sciences, Joint School of Life Sciences,Guangzhou Institutes of Biomedicine and Health and Guangzhou Medical University, 5Laboratory of RNA, Chromatin, and Human Disease, CAS Key Laboratory of Regenerative Biology and Guangdong Provincial Key Laboratory of Stem Cells and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health,Chinese Academy of Sciences, 6Research Centre of Heart, Brain, Hormone, and Healthy Ageing, Li Ka Shing Faculty of Medicine,University of Hong Kong, 7Hong Kong-Guangdong Stem Cell and Regenerative Medicine Research Centre,University of Hong Kong and Guangzhou Institutes of Biomedicine and Health
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نقدم هنا، وضع بروتوكول لإنشاء نموذج ماوس تشيميريك كبد البشري من الكوليستيرول الأسرية باستخدام خلايا الكبد المشتقة من الخلايا الجذعية البشرية المستحثة pluripotent. وهذا نموذجا قيماً لاختبار علاجات جديدة الكوليستيرول.
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Yang, J., Wong, L., Tian, X., Wei, R., Lai, W., Au, K., Luo, Z., Ward, C., Ho, W., Ibañez, D. P., Liu, H., Bao, X., Qin, B., Huang, Y., Esteban, M. A., Tse, H. A Familial Hypercholesterolemia Human Liver Chimeric Mouse Model Using Induced Pluripotent Stem Cell-derived Hepatocytes. J. Vis. Exp. (139), e57556, doi:10.3791/57556 (2018).
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