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A Mouse Model of Orthopedic Surgery to Study Postoperative Cognitive Dysfunction and Tissue Regeneration
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Medicine
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JoVE Journal Medicine
A Mouse Model of Orthopedic Surgery to Study Postoperative Cognitive Dysfunction and Tissue Regeneration

A Mouse Model of Orthopedic Surgery to Study Postoperative Cognitive Dysfunction and Tissue Regeneration

English

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15,813 Views

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08:17 min

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February 27, 2018

DOI:

10.3791/56701-v

DOI:
10.3791/56701-v

•

08:17 min
February 27, 2018

•

59 Views
, , ,
1Department of Anesthesiology,Duke University Medical Center, 2Department of Orthopaedic Surgery,Duke University Medical Center, 3Duke Molecular Physiology Institute, 4Center for Translational Pain Medicine,Duke University Medical Center

Summary

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This protocol describes a mouse model of orthopedic surgery that has been used to study mechanisms of postoperative neuroinflammation and behavioral changes, and when combined with parabiosis, to study tissue regeneration during aging.

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Orthopedic SurgeryParabiosisPostoperative Cognitive DysfunctionImmunologyAgingTraumaMulti-organ DysfunctionRegenerative EffectsCognitive FunctionAnesthesiaAnalgesiaSurgical Procedure

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Cite this Article

Xiong, C., Zhang, Z., Baht, G. S., Terrando, N. A Mouse Model of Orthopedic Surgery to Study Postoperative Cognitive Dysfunction and Tissue Regeneration. J. Vis. Exp. (132), e56701, doi:10.3791/56701 (2018).

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