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Establishing Mouse Models for Zika Virus-induced Neurological Disorders Using Intracerebral Injection Strategies: Embryonic, Neonatal, and Adult
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Neuroscience
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JoVE Journal Neuroscience
Establishing Mouse Models for Zika Virus-induced Neurological Disorders Using Intracerebral Injection Strategies: Embryonic, Neonatal, and Adult

Establishing Mouse Models for Zika Virus-induced Neurological Disorders Using Intracerebral Injection Strategies: Embryonic, Neonatal, and Adult

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8,436 Views

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09:39 min

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April 26, 2018

DOI:

10.3791/56486-v

DOI:
10.3791/56486-v

•

09:39 min
April 26, 2018

•

10 Views
, , , ,
1Biomedical and Health Sciences Institute,University of Georgia, 2Center for Craniofacial Molecular Biology,University of Southern California, 3Department of Infectious Diseases, College of Veterinary Medicine,University of Georgia

Summary

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Here we describe a method for establishing a model of Zika virus-induced microcephaly in mouse. This protocol includes methods for embryonic, neonatal, and adult-stage intracerebral inoculation of the Zika virus.

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Zika VirusMouse ModelIntracerebral InjectionEmbryonicNeonatalAdultIn VivoBrain InfectionMicrocephalyNeuro-developmental DisordersFlavivirusDengue VirusSurgical ProcedureAnesthesiaEmbryo ExposureVirus Inoculation

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Herrlinger, S. A., Shao, Q., Ma, L., Brindley, M., Chen, J. Establishing Mouse Models for Zika Virus-induced Neurological Disorders Using Intracerebral Injection Strategies: Embryonic, Neonatal, and Adult. J. Vis. Exp. (134), e56486, doi:10.3791/56486 (2018).

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