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Generation af prostatakræft Cell modeller af resistens over for anti-mitotiske Agent Docetaxel
JoVE Journal
Cancer Research
This content is Free Access.
JoVE Journal Cancer Research
Generation of Prostate Cancer Cell Models of Resistance to the Anti-mitotic Agent Docetaxel
DOI:

06:44 min

September 08, 2017

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Chapters

  • 00:05Title
  • 00:52Generation of Docetaxel-resistant Prostate Cancer Cells
  • 03:33Functional Characterization of Acquired Docetaxel Resistance by Colony Formation Assay
  • 05:10Results: Generation of Docetaxel-resistant Prostate Cancer Cell Model Systems and Functional Characterization of Docetaxel Resistance
  • 06:14Conclusion

Summary

Automatic Translation

Resistens over for kræft behandlinger bidrager til sygdomsprogression og død. Bestemmelse af de mekanistiske fundament for modstand er afgørende for at forbedre terapeutisk respons. Dette manuskript detaljer protokol til at generere taxane-resistente cell modeller af prostatacancer (PC) til at dissekere veje, der er involveret i progression til Docetaxel modstand i PC patienter.

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