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Induction of Paralysis and Visual System Injury in Mice by T Cells Specific for Neuromyelitis Optica Autoantigen Aquaporin-4

JoVE Journal
Immunology and Infection

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JoVE Journal Immunology and Infection

Induction of Paralysis and Visual System Injury in Mice by T Cells Specific for Neuromyelitis Optica Autoantigen Aquaporin-4

Induction of Paralysis and Visual System Injury in Mice by T Cells Specific for Neuromyelitis Optica Autoantigen Aquaporin-4

10,919 Views

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09:29 min

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August 21, 2017

DOI:

10.3791/56185-v

DOI:

10.3791/56185-v

•

09:29 min

August 21, 2017

•

1 Views

Sharon A. Sagan*^1,2, Andrés Cruz-Herranz*¹, Collin M. Spencer², Peggy P. Ho, Lawrence Steinman, Ari J. Green, Raymond A. Sobel, Scott S. Zamvil²

¹Department of Neurology,University of California, ²Program in Immunology,University of California, ³Department of Neurology and Neurological Sciences,Stanford University, ⁴Department of Pathology,Stanford University

Tags

Neuromyelitis Optica Aquaporin-4 T Cells Adoptive Transfer Central Nervous System Autoimmune Disease Optical Coherence Tomography Retinal Injury Complete Freund’s Adjuvant Emulsion Subcutaneous Injection

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