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自发交替评估,淀粉样蛋白β和脑神经病理学转基因小鼠模型中的新物体识别和肢体紧扣
JoVE Journal
Medicine
This content is Free Access.
JoVE Journal
Medicine
Assessment of Spontaneous Alternation, Novel Object Recognition and Limb Clasping in Transgenic Mouse Models of Amyloid-β and Tau Neuropathology
Please note that all translations are automatically generated.
Click here for the English version.
自发交替评估,淀粉样蛋白β和脑神经病理学转基因小鼠模型中的新物体识别和肢体紧扣
DOI:
10.3791/55523-v
•
10:02 min
•
May 28, 2017
•
Christian J. Miedel
,
Jennifer M. Patton
,
Andrew N. Miedel
,
Edward S. Miedel
,
Jonathan M. Levenson
1
Hilltop Laboratory Animals
,
2
Preclinical Research & Development
,
Proclara Biosciences, Inc.
Chapters
00:05
Title
00:58
Y-Maze Working Memory Test
02:37
Novel Object Intermediate-term Memory Test
06:01
Limb Clasping Corticospinal Function Test
07:25
Results: Test Results
09:14
Concusion
Summary
Automatic Translation
English (Original)
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Automatic Translation
这里描述的是一种分阶段的行为筛选方法,可用于筛选在β淀粉样变性和tau蛋白病的转基因小鼠模型中
对体内
功效的认知功能运动行为进行筛选的化合物。这些方法被优化以筛选化合物用于短期和工作记忆任务中的活动。
Tags
Alzheimer’s Disease
Transgenic Mouse Models
Amyloid-β
Tau
Spontaneous Alternation
Novel Object Recognition
Limb Clasping
Preclinical Drug Discovery
Y-maze
Open Field Arena
Behavior Assessment
Dementia
Cognitive Dysfunction
Frontotemporal Dementia
Traumatic Brain Injury
Autism
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