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Fabrication of Extracellular Matrix-derived Foams and Microcarriers as Tissue-specific Cell Culture and Delivery Platforms
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April 11, 2017
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1Biomedical Engineering Graduate Program,The University of Western Ontario, 2Department of Anatomy & Cell Biology, Schulich School of Medicine & Dentistry,The University of Western Ontario, 3Department of Chemical Engineering,Queen’s University, 4Department of Chemical & Biochemical Engineering, Faculty of Engineering,The University of Western Ontario
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The tissue-specific extracellular matrix (ECM) is a key mediator of cell function. This article describes methods for synthesizing pure ECM-derived foams and microcarriers that are stable in culture without the need for chemical crosslinking for applications in advanced 3D in vitro cell culture models or as pro-regenerative bioscaffolds.
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Kornmuller, A., Brown, C. F., Yu, C., Flynn, L. E. Fabrication of Extracellular Matrix-derived Foams and Microcarriers as Tissue-specific Cell Culture and Delivery Platforms. J. Vis. Exp. (122), e55436, doi:10.3791/55436 (2017).
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