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Mesenchymal Stromal Cell Culture and Delivery in Autologous Conditions: A Smart Approach for Orthopedic Applications
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December 08, 2016
DOI:
1Dept. of Clinical and Experimental Medicine,University of Pisa, 2OtoLab,Azienda Ospedaliero-Universitaria Pisana (AOUP), 3Dept. of Civil and Industrial Engineering,University of Pisa, 4Immunohematology Operative Unit,Azienda Ospedaliero-Universitaria Pisana (AOUP), 5Dept. Of Surgical, Medical, Molecular Pathology and Emergency Medicine,University of Pisa, 6II Orthopedic and Traumatologic Clinic,Azienda Ospedaliero-Universitaria Pisana (AOUP)
Summary
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Culturing human Mesenchymal Stromal Cells (hMSCs) with autologous serum, reduces the risks of rejection by xenogeneic material and other negative effects. It also allows for the recovery of a subset of mesodermal progenitors, which can deliver fresh hMSCs. Embedding hMSCs in an autologous fibrin clot enables easy handling and effective surgical implantation.
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Trombi, L., Danti, S., Savelli, S., Moscato, S., D'Alessandro, D., Ricci, C., Giannotti, S., Petrini, M. Mesenchymal Stromal Cell Culture and Delivery in Autologous Conditions: A Smart Approach for Orthopedic Applications. J. Vis. Exp. (118), e54845, doi:10.3791/54845 (2016).
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