Los enfoques genéticos y bioquímicos para<em> En Vivo</em> y<em> In Vitro</em> Evaluación de la oligomerización de proteínas el receptor de rianodina Estudio de caso

Oligomerization of the ryanodine receptor, a homo-tetrameric ion channel mediating Ca²⁺ release from intracellular stores, is critical for skeletal and cardiac muscle contraction. Here, we present complementary in vivo and in vitro methods to detect protein self-association and determine homo-oligomer stoichiometry.