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Haut Analyse de dépistage du contenu pour évaluer les effets toxicologiques des composants nocifs et potentiellement dangereux (HPHC)
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Biology
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JoVE Journal Biology
High Content Screening Analysis to Evaluate the Toxicological Effects of Harmful and Potentially Harmful Constituents (HPHC)
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Haut Analyse de dépistage du contenu pour évaluer les effets toxicologiques des composants nocifs et potentiellement dangereux (HPHC)

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11,757 Views

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11:38 min

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May 10, 2016

DOI:

10.3791/53987-v

DOI:
10.3791/53987-v

•

11:38 min
May 10, 2016

•

4 Views
, , , , , , ,
1Biological System Research (BSR),Philip Morris International R&D

Summary

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The objective of the study was to assess the biological impact of 15 cigarette smoke constituents using a combination of an impedance-based real time cell analyzer and a high-content screening (HCS)-based platform for toxicological assessment in vitro. This study provides information on effective doses, toxicity and modes of action of the tested compounds.

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Cite this Article

Marescotti, D., Gonzalez Suarez, I., Acali, S., Johne, S., Laurent, A., Frentzel, S., Hoeng, J., Peitsch, M. C. High Content Screening Analysis to Evaluate the Toxicological Effects of Harmful and Potentially Harmful Constituents (HPHC). J. Vis. Exp. (111), e53987, doi:10.3791/53987 (2016).

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