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La endotoxina intravenosa Challenge en seres humanos sanos: una plataforma experimental para investigar y modular la inflamación sistémica
JoVE Journal
Medicine
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JoVE Journal Medicine
Intravenous Endotoxin Challenge in Healthy Humans: An Experimental Platform to Investigate and Modulate Systemic Inflammation
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La endotoxina intravenosa Challenge en seres humanos sanos: una plataforma experimental para investigar y modular la inflamación sistémica

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11,268 Views

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07:48 min

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May 16, 2016

DOI:

10.3791/53913-v

DOI:
10.3791/53913-v

•

07:48 min
May 16, 2016

•

1 Views
, , , ,
1Centre for Clinical Pharmacology, Division of Medicine,University College London

Summary

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Intravenous administration of endotoxin reliably elicits dose-dependent physiological and immunological alterations consistent with several pathological states. This reductionist approach permits the investigation, modeling and experimental modification of systemic inflammation and its downstream effects in man.

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Cite this Article

Fullerton, J. N., Segre, E., De Maeyer, R. P., Maini, A. A., Gilroy, D. W. Intravenous Endotoxin Challenge in Healthy Humans: An Experimental Platform to Investigate and Modulate Systemic Inflammation. J. Vis. Exp. (111), e53913, doi:10.3791/53913 (2016).

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