Stabile ed efficiente Modificazione genetica di cellule nel topo adulto V-SVZ per l'analisi di cellule staminali neurali autonoma ed effetti non autonomi
Here we describe a procedure based on the use of lentiviral particles for the long-term genetic modification of neural stem cells and/or their adjacent ependymal cells in the adult ventricular-subventricular neurogenic niche which allows the separate analysis of cell autonomous and non-autonomous, niche-dependent effects on neural stem cells.