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La linfa mesenterica Duct Cannulated Rat Modello: Applicazione alla valutazione di intestinale linfatico Drug Transport
JoVE Journal
Immunology and Infection
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JoVE Journal Immunology and Infection
The Mesenteric Lymph Duct Cannulated Rat Model: Application to the Assessment of Intestinal Lymphatic Drug Transport

La linfa mesenterica Duct Cannulated Rat Modello: Applicazione alla valutazione di intestinale linfatico Drug Transport

27,932 Views

13:17 min

March 06, 2015

DOI:

13:17 min
March 06, 2015

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Summary

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Here we describe a technique to cannulate the mesenteric lymph duct in rats which enables quantification of lipid and drug transport via the lymphatic system following intestinal delivery. The technique can be adapted to assess mesenteric lymph concentrations and/or transport of fluid, immune cells, peptides, proteins and lipophilic molecules.

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