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May 04, 2015
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A highly reproducible model for myocardial infarction in mice with minimal invasive manipulations is described. The model can be easily performed, resulting in a high reproducibility and survival rate. Thus, the described model will reduce the number of required animals as requested by the 3R principle (Replacement, Refinement and Reduction).
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Curaj, A., Simsekyilmaz, S., Staudt, M., Liehn, E. Minimal Invasive Surgical Procedure of Inducing Myocardial Infarction in Mice. J. Vis. Exp. (99), e52197, doi:10.3791/52197 (2015).
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