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Modeling Mucosal Candidiasis in Larval Zebrafish by Swimbladder Injection
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Immunology and Infection
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JoVE Journal Immunology and Infection
Modeling Mucosal Candidiasis in Larval Zebrafish by Swimbladder Injection

Modeling Mucosal Candidiasis in Larval Zebrafish by Swimbladder Injection

English

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10,001 Views

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06:28 min

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November 27, 2014

DOI:

10.3791/52182-v

DOI:
10.3791/52182-v

•

06:28 min
November 27, 2014

•

3 Views
, ,
1Department of Molecular and Biomedical Sciences,University of Maine, 2Graduate School of Biomedical Sciences and Engineering,University of Maine

Summary

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In vivo spatio-temporal interactions of pathogen and immune defenses at the mucosal level are not easily imaged in existing vertebrate hosts. The method presented here describes a versatile platform to study mucosal candidiasis in live vertebrates using the swimbladder of the juvenile zebrafish as an infection site.

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Cite this Article

Gratacap, R. L., Bergeron, A. C., Wheeler, R. T. Modeling Mucosal Candidiasis in Larval Zebrafish by Swimbladder Injection. J. Vis. Exp. (93), e52182, doi:10.3791/52182 (2014).

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