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An Isolated Working Heart System for Large Animal Models
JoVE Journal
Medicine
This content is Free Access.
JoVE Journal Medicine
An Isolated Working Heart System for Large Animal Models
DOI:

09:45 min

June 11, 2014

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Chapters

  • 00:05Title
  • 01:07Building the Langendorff Apparatus
  • 02:45Preparing the Langendorff Apparatus
  • 03:48Attaching the Heart to the Langendorff
  • 05:58Obtaining Ventricular Pressure-Volume (PV) Recordings
  • 07:37Results: Representative PV recordings
  • 09:20Conclusion

Summary

Automatic Translation

Most studies involving the Langendorff apparatus use small animal models due to the increased complexity of systems for larger mammals. We describe a Langendorff system for large animal models that allows for use across a range of species, including humans, and relatively easy data acquisition.

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