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The Utilization of Oropharyngeal Intratracheal PAMP Administration and Bronchoalveolar Lavage to Evaluate the Host Immune Response in Mice
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Immunology and Infection
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JoVE Journal Immunology and Infection
The Utilization of Oropharyngeal Intratracheal PAMP Administration and Bronchoalveolar Lavage to Evaluate the Host Immune Response in Mice

The Utilization of Oropharyngeal Intratracheal PAMP Administration and Bronchoalveolar Lavage to Evaluate the Host Immune Response in Mice

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16,443 Views

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12:27 min

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April 02, 2014

DOI:

10.3791/51391-v

DOI:
10.3791/51391-v

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12:27 min
April 02, 2014

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5 Views
1Department of Biomedical Sciences and Pathobiology, Virginia-Maryland Regional College of Veterinary Medicine,Virginia Polytechnic Institute and State University

Summary

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The host immune response to pathogen infection is a tightly regulated process. Utilizing a lipopolysaccharide lung exposure model in mice, it is possible to conduct high resolution evaluations of the complex mechanisms associated with disease pathogenesis.

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Oropharyngeal Intratracheal AdministrationBronchoalveolar LavageHost Immune ResponseLipopolysaccharidePAMPAcute Lung InflammationInnate ImmunityHost-pathogen InteractionMouse Model

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Allen, I. C. The Utilization of Oropharyngeal Intratracheal PAMP Administration and Bronchoalveolar Lavage to Evaluate the Host Immune Response in Mice. J. Vis. Exp. (86), e51391, doi:10.3791/51391 (2014).

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