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Automated, Quantitative Cognitive/Behavioral Screening of Mice: For Genetics, Pharmacology, Animal Cognition and Undergraduate Instruction
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JoVE Journal Behavior
Automated, Quantitative Cognitive/Behavioral Screening of Mice: For Genetics, Pharmacology, Animal Cognition and Undergraduate Instruction

Automated, Quantitative Cognitive/Behavioral Screening of Mice: For Genetics, Pharmacology, Animal Cognition and Undergraduate Instruction

DOI:
10.3791/51047-v

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16:23 min

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February 26, 2014

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, , , ,
1Department of Psychology,Rutgers University, 2Department of Psychology,Koç University, 3Center for Neural Science,New York University, 4Department of Mathematics & Computer Science,Fairfield University

Chapters

  • 00:05Title
  • 02:12Setting Up the Physical System
  • 03:23Setting Up the Software System
  • 04:10Starting an Experiment
  • 05:39Data Analysis
  • 07:04Results: Automated Psychophysics in the Mouse
  • 15:56Conclusion

Summary

Automatic Translation

Automatic Translation

Fully automated system for measuring physiologically meaningful properties of the mechanisms mediating spatial localization, temporal localization, duration, rate and probability estimation, risk assessment, impulsivity, and the accuracy and precision of memory, in order to assess the effects of genetic and pharmacological manipulations on foundational mechanisms of cognition in mice.

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Keywords: AutomatedQuantitativeCognitiveBehavioralScreeningMiceGeneticsPharmacologyAnimal CognitionUndergraduate InstructionHigh-throughputHigh-volumeFully AutomatedLive-in24/7Behavioral Testing SystemPolypropylene Mouse HousingAcrylic TubeMouse Test BoxHoppersPellet FeedersInfrared BeamsOperantPavlovianProtocol-control SoftwareData AnalysisGraphing SoftwareMATLABTime-stamped Behavioral And Physiological Event RecordsStatistical AnalysisGraphical AnalysisCloud StorageMatchingAutoshapingTimed Hopper-switchingRisk AssessmentImpulsivity MeasurementCircadian AnticipationOpen-sourceProtocol-control CodeData-analysis Code

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