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February 02, 2014
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Prophylactic and therapeutic vaccination often fails to stimulate strong immune responses due to week drainage of the vaccine to lymph nodes and consequently poor involvement of immune cells. By direct injection of vaccine to lymph nodes, so-called intralymphatic injection, vaccine efficacy can be strongly improved and vaccine doses can be reduced.
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Intralymphatic ImmunotherapyIntralymphatic VaccinationLymph Node InjectionLymph Node TargetingVaccine DeliveryImmune Response EnhancementSubcutaneous VaccinationIntramuscular VaccinationAntigen PresentationLymphocyte ActivationVaccine MicroenvironmentCytokinesPlasmid DNARNAPeptideProteinParticlesBacteriaAdjuvants
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Johansen, P., Kündig, T. M. Intralymphatic Immunotherapy and Vaccination in Mice. J. Vis. Exp. (84), e51031, doi:10.3791/51031 (2014).
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