En Reprogramación vivo de células somáticas de adultos a Pluripotencia por la sobreexpresión de factores de Yamanaka

This study demonstrates the reprogramming of somatic cells towards pluripotency in vivo without the generation of teratomas. We used hydrodynamic tail vein injection of plasmid DNA encoding the Yamanka factors to induce the in vivo reprogramming of adult hepatocytes into cells of enhanced pluripotency.