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Long-term Potentiation of Perforant Pathway-dentate Gyrus Synapse in Freely Behaving Mice
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JoVE Journal Behavior
Long-term Potentiation of Perforant Pathway-dentate Gyrus Synapse in Freely Behaving Mice

Long-term Potentiation of Perforant Pathway-dentate Gyrus Synapse in Freely Behaving Mice

DOI:
10.3791/50642-v

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11:13 min

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November 29, 2013

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1Department of Engineering and Neuroscience Program,Trinity College

Chapters

  • 00:05Title
  • 01:23Animal Preparation and Surgical Procedures
  • 07:47LTP Production
  • 10:06Results: Long-term Potentiation of Perforant Pathway-dentate Gyrus Synapse in Freely Behaving Mice
  • 10:34Conclusion

Summary

Automatic Translation

Automatic Translation

Transgenic and knockout mouse models of neurological diseases are useful for studying the role of genes in normal and abnormal neurophysiology. This article describes methodologies which can be used to study long-term potentiation, a cellular mechanism which may underlie learning and memory, in transgenic and knockout freely behaving mouse models of neuropathology.

Tags

Long-term PotentiationLTPPerforant PathwayDentate GyrusHippocampusFreely Behaving MiceTransgenic Mouse ModelsNeurological DiseasesSynaptic CommunicationNeuronal NetworksLearningEmotionInformation Processing

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