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April 17, 2013
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Generation of an orthotopic mouse model of anaplastic thyroid carcinoma is described here. This technique employs surgical placement of human anaplastic thyroid cancer cells into the thyroid of immunodeficient mice, thus creating a more clinically relevant setting to study disease progression as well as screen innovative therapeutic interventions.
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Sewell, W., Reeb, A., Lin, R. An Orthotopic Mouse Model of Anaplastic Thyroid Carcinoma. J. Vis. Exp. (74), e50097, doi:10.3791/50097 (2013).
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