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实时成像在乳腺癌小鼠模型中的肿瘤微环境对药物的反应

JoVE Journal
Medicine

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JoVE Journal Medicine

Live Imaging of Drug Responses in the Tumor Microenvironment in Mouse Models of Breast Cancer

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实时成像在乳腺癌小鼠模型中的肿瘤微环境对药物的反应

DOI:

10.3791/50088-v

•

08:26 min

•

March 24, 2013

•

Elizabeth S. Nakasone², Hanne A. Askautrud³, Mikala Egeblad

¹Watson School of Biological Sciences, ²Cold Spring Harbor Laboratory, ³Departments of Medical Genetics,University of Oslo and Oslo University Hospital

Chapters

00:05Title
01:16Pre-treatment of Animals for Imaging and Preparation of Surgical Tools and Platform
02:31Exposing the Inguinal Mammary Gland for Imaging
04:21Positioning the Mouse on the Stage
06:16Representative Live Imaging Results
08:06Conclusion

Summary

Automatic Translation

我们描述了一种方法，成像响应于抗肿瘤治疗的<em在体内</em在单细胞分辨率。

Tags

Keywords: Live Imaging Drug Response Tumor Microenvironment Mouse Models Breast Cancer 3D Co-culture Tumor-stroma Interactions Spinning Disk Confocal Microscopy Systemic Therapy Cell Labeling Surgical Procedure Time-lapse Movies Image Analysis

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