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Simultaneous Intracellular Recording of a Lumbar Motoneuron and the Force Produced by its Motor Unit in the Adult Mouse In vivo
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December 05, 2012
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This new method permits the simultaneous intracellular recording of a single adult mouse motoneuron and the measurement of the force produced by its muscle fibers. The combined investigation of the electrical and mechanical properties of motor units in normal and genetically modified animals is a breakthrough for the study of the neuromuscular system.
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Simultaneous Intracellular RecordingLumbar MotoneuronForce ProducedMotor UnitAdult MouseIn VivoNeural FunctionCentral Nervous SystemMuscle ContractionFinal Common PathwaySharp Intracellular ElectrodesElectrical ActivityMuscle TargetsIntracellular RecordingsMotor Unit CompartmentsInputs ImpingingElectrophysiological PropertiesPhysiological FunctionChallenging PreparationMechanical Stability
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Manuel, M., Heckman, C. Simultaneous Intracellular Recording of a Lumbar Motoneuron and the Force Produced by its Motor Unit in the Adult Mouse In vivo. J. Vis. Exp. (70), e4312, doi:10.3791/4312 (2012).
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