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Detection of Invasive Pulmonary Aspergillosis in Haematological Malignancy Patients by using Lateral-flow Technology
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March 22, 2012
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A rapid and accurate point-of-care test for invasive pulmonary aspergillosis is presented. It takes advantage of lateral-flow technology using a specific monoclonal antibody that binds to an Aspergillus antigen secreted during pulmonary infections. The assay is compatible with serum and brochoalveolar lavage and represents a novel adjunct test for disease diagnosis.
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Invasive Pulmonary AspergillosisHaematological MalignancyLateral-flow TechnologyDiagnostic ChallengeMicrobiologyHistopathologyEuropean Organization For Research And Treatment Of CancerNational Institute Of Allergy And Infectious Diseases Mycology Study GroupNucleic Acid-based TestsPolymerase Chain ReactionAspergillus IdentificationHyphal MorphologiesInvasive Fungal PathogensCulture-based ApproachesBiopsy SamplesPathogenesisAngio-invasion
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Thornton, C., Johnson, G., Agrawal, S. Detection of Invasive Pulmonary Aspergillosis in Haematological Malignancy Patients by using Lateral-flow Technology. J. Vis. Exp. (61), e3721, doi:10.3791/3721 (2012).
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