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Crystallization of ABC Transporter Membrane Proteins in Lipidic Bicelles
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Author Spotlight: A Bicelle Crystallization Setup for ABC Transporter Membrane Proteins to Advance Drug Development
JoVE Journal
Biyokimya
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JoVE Journal Biyokimya
ABCG5/G8 Crystallization in a Lipidic Bicelle Environment for X-Ray Crystallography

Author Spotlight: A Bicelle Crystallization Setup for ABC Transporter Membrane Proteins to Advance Drug Development

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01:55 min

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August 25, 2023

DOI:

10.3791/65828-v

DOI:
10.3791/65828-v

•

01:55 min
August 25, 2023

•

8 Views
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1Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine,University of Ottawa, 2Department of Biochemistry, Faculty of Medicine and Dentistry,Alberta Üniversitesi

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ABCG5/G8Membrane ProteinATP-binding Cassette TransporterX-ray CrystallographyLipidic BicelleStructural StudiesDrug DiscoveryLipid RecognitionLipid TranslocationMembrane Protein StructureDetergentPhospholipidBicelle

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Wazir, S., Farhat, D., Srinivasan, M., Lee, J. ABCG5/G8 Crystallization in a Lipidic Bicelle Environment for X-Ray Crystallography. J. Vis. Exp. (198), e65828, doi:10.3791/65828 (2023).

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