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Open-Source Real-Time Closed-Loop Electrical Threshold Tracking for Translational Pain Research
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10:28 min
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April 21, 2023
DOI:
1Anaesthesia, Pain, and Critical Care Sciences, School of Physiology, Pharmacology, & Neuroscience,University of Bristol, 2Eli Lilly and Company, 3Department of Computer Science,University of Bristol, 4Department of Aerospace Engineering,University of Bristol, 5Research Computing,University of Bristol
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APTrack is a software plugin developed for the Open Ephys platform that enables real-time data visualization and the closed-loop electrical threshold tracking of neuronal action potentials. We have successfully used this in microneurography for human C-fiber nociceptors and mouse C-fiber and Aδ-fiber nociceptors.
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Nickerson, A. P., Newton, G. W. T., O'Sullivan, J. H., Martinez-Perez, M., Sales, A. C., Williams, G., Pickering, A. E., Dunham, J. P. Open-Source Real-Time Closed-Loop Electrical Threshold Tracking for Translational Pain Research. J. Vis. Exp. (194), e64898, doi:10.3791/64898 (2023).
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