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A Method to Study the Correlation Between Local Collagen Structure and Mechanical Properties of Atherosclerotic Plaque Fibrous Tissue
JoVE Journal
Biyomühendislik
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A Method to Study the Correlation Between Local Collagen Structure and Mechanical Properties of Atherosclerotic Plaque Fibrous Tissue

A Method to Study the Correlation Between Local Collagen Structure and Mechanical Properties of Atherosclerotic Plaque Fibrous Tissue

1,724 Views

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13:45 min

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November 11, 2022

DOI:

10.3791/64334-v

DOI:
10.3791/64334-v

•

13:45 min
November 11, 2022

•

3 Views
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1Department of Biomedical Engineering,Erasmus Medical Center, 2Department of Biomedical Engineering,Eindhoven University of Technology, 3Department of Biomechanical Engineering,Delft University of Technology, 4Erasmus Optical Imaging Center,Erasmus Medical Center

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We have developed a mechano-imaging pipeline to study the heterogeneous structural and mechanical atherosclerotic plaque properties. This pipeline enables correlation of the local predominant angle and dispersion of collagen fiber orientation, the rupture behavior, and the strain fingerprints of the fibrous plaque tissue.

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Crielaard, H., Guvenir Torun, S., Wissing, T. B., de Miguel Muñoz, P., Kremers, G., Gijsen, F. J. H., Van Der Heiden, K., Akyildiz, A. C. A Method to Study the Correlation Between Local Collagen Structure and Mechanical Properties of Atherosclerotic Plaque Fibrous Tissue. J. Vis. Exp. (189), e64334, doi:10.3791/64334 (2022).

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