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Delivery of Cardioactive Therapeutics in a Porcine Myocardial Infarction Model
JoVE Journal
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Delivery of Cardioactive Therapeutics in a Porcine Myocardial Infarction Model

Delivery of Cardioactive Therapeutics in a Porcine Myocardial Infarction Model

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07:20 min

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February 10, 2023

DOI:

10.3791/64177-v

DOI:
10.3791/64177-v

•

07:20 min
February 10, 2023

•

13 Views
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1Centre for Heart Research, The Westmead Institute for Medical Research,The University of Sydney, 2Department of Cardiology,Westmead Hospital, 3Sydney Imaging, Core Research Facility,The University of Sydney, 4Department of Cardiothoracic Surgery,Liverpool Hospital

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The present protocol describes three methods of administering cardioactive therapeutic agents in a porcine model. Female landrace swine received treatment through either: (1) thoracotomy and transepicardial injection, (2) catheter-based transendocardial injection, or (3) intravenous infusion via jugular vein osmotic minipump.

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Selvakumar, D., Wilkie, E., Deshmukh, T., Ravindran, D., Kotake, Y., Lu, J., Barry, T., Tran, V., Paterson, H., Hing, A., Campbell, T., Kumar, S., Kizana, E., Chong, J. J. H. Delivery of Cardioactive Therapeutics in a Porcine Myocardial Infarction Model. J. Vis. Exp. (192), e64177, doi:10.3791/64177 (2023).

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