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Inducing Post-Traumatic Epilepsy in a Mouse Model of Repetitive Diffuse Traumatic Brain Injury
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Inducing Post-Traumatic Epilepsy in a Mouse Model of Repetitive Diffuse Traumatic Brain Injury

Inducing Post-Traumatic Epilepsy in a Mouse Model of Repetitive Diffuse Traumatic Brain Injury

10,065 Views

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07:07 min

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February 10, 2020

DOI:

10.3791/60360-v

DOI:
10.3791/60360-v

•

07:07 min
February 10, 2020

•

25 Views
,
1Fralin Biomedical Research Institute at Virginia Tech Carilion, 2School of Neuroscience,Virginia Tech, 3Department of Biological Sciences,Virginia Tech

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This systematic protocol describes a new animal model of post-traumatic epilepsy after repetitive mild traumatic brain injury. The first part details steps for traumatic brain injury induction using a modified weight drop model. The second part provides instructions on the surgical approach for single- and multi-channel electroencephalographic data acquisition systems.

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Cite this Article

Shandra, O., Robel, S. Inducing Post-Traumatic Epilepsy in a Mouse Model of Repetitive Diffuse Traumatic Brain Injury. J. Vis. Exp. (156), e60360, doi:10.3791/60360 (2020).

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