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一种快速、定量的后向基因组转化和变异的多肽映射方法
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May 22, 2018
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1Department of Neurobiology, F. M. Kirby Neurobiology Center,Boston Children’s Hospital, Harvard Medical School, 2Proteomic Mass Spectrometry,Wellcome Trust Sanger Institute, Wellcome Genome Campus, 3Centre for Molecular Informatics, Department of Chemistry,University of Cambridge, 4Functional Proteomics Group, Chester Beatty Laboratories,Institute of Cancer Research
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在这里, 我们提出了 proteogenomic 工具的弹跳和协议的快速, 数量, 后平移修改和变种启用映射的肽识别通过质谱的参考基因组。该工具用于集成和可视化 proteogenomic 和个人蛋白质组学的研究, 并与正交基因学数据相衔接。
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Schlaffner, C. N., Pirklbauer, G. J., Bender, A., Steen, J. A., Choudhary, J. S. A Fast and Quantitative Method for Post-translational Modification and Variant Enabled Mapping of Peptides to Genomes. J. Vis. Exp. (135), e57633, doi:10.3791/57633 (2018).
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