We present a method which can provide further insights into the early events underlying neurodegeneration and based on the established ex-vivo brain technique, combining the advantages of in vivo and in vitro experiments. Moreover, it represents a unique opportunity for direct comparison of treated and untreated group in the same anatomical plane.
Brai, E., Cogoni, A., Greenfield, S. A. An Alternative Approach to Study Primary Events in Neurodegeneration Using Ex Vivo Rat Brain Slices. J. Vis. Exp. (134), e57507, doi:10.3791/57507 (2018).