Mild intrauterine hypoperfusion was produced by artery stenosis with metal microcoils wrapped around the uterine and ovarian arteries in rats at embryonic day 17. This procedure produced prenatal hypoperfusion and intrauterine growth restriction.
Tsuji, M., Coq, J., Ogawa, Y., Yamamoto, Y., Ohshima, M. A Rat Model of Mild Intrauterine Hypoperfusion with Microcoil Stenosis. J. Vis. Exp. (131), e56723, doi:10.3791/56723 (2018).