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Quantification of Information Encoded by Gene Expression Levels During Lifespan Modulation Under Broad-range Dietary Restriction in C. elegans
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August 16, 2017
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1Centre for Developmental Neurobiology,King’s College London, 2Interdisciplinary Bioengineering Graduate Program,Georgia Institute of Technology, 3Wallace H. Coulter Department of Biomedical Engineering,Georgia Institute of Technology, 4School of Chemical & Biomolecular Engineering,Georgia Institute of Technology
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Here, we present a framework to relate broad-range dietary restriction to gene expression and lifespan. We describe protocols for broad-range dietary restriction and for quantitative imaging of gene expression under this paradigm. We further outline computational analyses to reveal underlying information processing features of the genetic circuits involved in food-sensing.
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Patel, D. S., Diana, G., Entchev, E. V., Zhan, M., Lu, H., Ch'ng, Q. Quantification of Information Encoded by Gene Expression Levels During Lifespan Modulation Under Broad-range Dietary Restriction in C. elegans. J. Vis. Exp. (126), e56292, doi:10.3791/56292 (2017).
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