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A Protocol for Measuring Cue Reactivity in a Rat Model of Cocaine Use Disorder
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07:51 min
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June 18, 2018
DOI:
1Center for Addiction Research,University of Texas Medical Branch, 2Institute for Translational Sciences,University of Texas Medical Branch, 3Mitchell Center for Neurodegenerative Diseases,University of Texas Medical Branch, 4Department of Neurology,University of Texas Medical Branch, 5Patoloji Bölümü,University of Texas Medical Branch, 6Department of Pharmacology and Toxicology,University of Texas Medical Branch
Özet
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Cue reactivity is conceptualized as sensitivity to cues linked with drug-taking experiences that contribute to craving and relapse in abstinent humans. Cue reactivity is modeled in rats by measuring attentional orientation toward drug-associated cues that results in appetitive approach behavior in a cue reactivity test following self-administration and forced abstinence.
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Dimet, A. L., Cisneros, I. E., Fox, R. G., Stutz, S. J., Anastasio, N. C., Cunningham, K. A., Dineley, K. T. A Protocol for Measuring Cue Reactivity in a Rat Model of Cocaine Use Disorder. J. Vis. Exp. (136), e55864, doi:10.3791/55864 (2018).
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