We present the technical challenges and solutions for obtaining reliable functional magnetic resonance imaging (fMRI) data from the human central olfactory system. This includes special considerations in olfactory fMRI paradigm design, descriptions of fMRI data acquisition with an MRI-compatible olfactometer, odorant selection, and a special software tool for data post-processing.
Wang, J., Rupprecht, S., Sun, X., Freiberg, D., Crowell, C., Cartisano, E., Vasavada, M., Yang, Q. X. A Free-breathing fMRI Method to Study Human Olfactory Function. J. Vis. Exp. (125), e54898, doi:10.3791/54898 (2017).