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Induction of Accelerated Atherosclerosis in Mice: The “Wire-Injury” Model
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August 25, 2020
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This study describes an invasive procedure for the induction of accelerated atherosclerosis in mice. In comparison to other methods using electric- or cryo-induced injury, mechanical-induced injury mimics the human condition of restenosis after revascularization therapies and is ideal for the study of the molecular mechanisms involved.
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Curaj, A., Zhoujun, W., Staudt, M., Liehn, E. A. Induction of Accelerated Atherosclerosis in Mice: The "Wire-Injury" Model. J. Vis. Exp. (162), e54571, doi:10.3791/54571 (2020).
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