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Development of a Backbone Cyclic Peptide Library as Potential Antiparasitic Therapeutics Using Microwave Irradiation
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January 26, 2016
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A simple and general method for the synthesis of cyclic peptides using microwave irradiation is outlined. This procedure enables the synthesis of backbone cyclic peptides with a collection of different conformations while retaining the side chains and the pharmacophoric moieties., and therefore, allows to screen for the bioactive conformation.
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Backbone Cyclic Peptide LibraryAntiparasitic TherapeuticsMicrowave IrradiationProtein-protein InteractionsAmino AcidActivatorActivator BasePolypropylene CartridgeCoupling ReactionNN-dimethylformamidePiperidine1-hydroxybenzotriazoleDichloromethane1-methyl-2-pyrrolidinoneAnhydride4-DimethylaminopyridineNN-diisopropylethylamineTrifluoroacetic AcidTriisopropylsilane
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Qvit, N., Kornfeld, O. S. Development of a Backbone Cyclic Peptide Library as Potential Antiparasitic Therapeutics Using Microwave Irradiation. J. Vis. Exp. (107), e53589, doi:10.3791/53589 (2016).
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