This protocol presents a method for creating a large unilateral craniotomy over the temporal and parietal regions of the mouse cerebral cortex. This is especially useful for real time imaging over an expansive area of a cortical hemisphere.
Kyweriga, M., Sun, J., Wang, S., Kline, R., Mohajerani, M. H. A Large Lateral Craniotomy Procedure for Mesoscale Wide-field Optical Imaging of Brain Activity. J. Vis. Exp. (123), e52642, doi:10.3791/52642 (2017).