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Methods for the Modulation and Analysis of NF-κB-dependent Adult Neurogenesis
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JoVE Journal Nörobilim
Methods for the Modulation and Analysis of NF-κB-dependent Adult Neurogenesis

Methods for the Modulation and Analysis of NF-κB-dependent Adult Neurogenesis

14,126 Views

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14:58 min

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February 13, 2014

DOI:

10.3791/50870-v

DOI:
10.3791/50870-v

•

14:58 min
February 13, 2014

•

2 Views
, , , , ,
1Cell Biology,University of Bielefeld, 2Molecular Neurobiology,University of Bielefeld

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Methods for the manipulation and analysis of NF-κB-dependent adult hippocampal neurogenesis are described. A detailed protocol is presented for a dentate gyrus-dependent behavioral test (termed the spatial pattern separation-Barnes maze) for the investigation of cognitive outcome in mice. This technique should also help enable investigations in other experimental settings.

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Widera, D., Müller, J., Imielski, Y., Heimann, P., Kaltschmidt, C., Kaltschmidt, B. Methods for the Modulation and Analysis of NF-κB-dependent Adult Neurogenesis. J. Vis. Exp. (84), e50870, doi:10.3791/50870 (2014).

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