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Synthesis of Phase-shift Nanoemulsions with Narrow Size Distributions for Acoustic Droplet Vaporization and Bubble-enhanced Ultrasound-mediated Ablation
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Synthesis of Phase-shift Nanoemulsions with Narrow Size Distributions for Acoustic Droplet Vaporization and Bubble-enhanced Ultrasound-mediated Ablation
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08:28 min
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September 13, 2012
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Phase-shift nanoemulsions (PSNE) can be vaporized using high intensity focused ultrasound to enhance localized heating and improve thermal ablation in tumors. In this report, the preparation of stable PSNE with a narrow size distribution is described. Furthermore, the impact of vaporized PSNE on ultrasound-mediated ablation is demonstrated in tissue-mimicking phantoms.
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SynthesisPhase-shift NanoemulsionsNarrow Size DistributionsAcoustic Droplet VaporizationBubble-enhanced Ultrasound-mediated AblationHigh-intensity Focused Ultrasound (HIFU)Lipid-coated Perfluorocarbon DropletsLocalized HeatingThermal AblationTumorsVasculatureNanoparticlesFenestrationsPassive AccumulationDroplet Size ControlPreparationStable DropletsSonicatingLiquid PerfluorocarbonExtrusionFiltersPore SizesSize Distribution MeasurementDynamic Light ScatteringPolyacrylamide HydrogelsIn Vitro Experiments
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Kopechek, J. A., Zhang, P., Burgess, M. T., Porter, T. M. Synthesis of Phase-shift Nanoemulsions with Narrow Size Distributions for Acoustic Droplet Vaporization and Bubble-enhanced Ultrasound-mediated Ablation. J. Vis. Exp. (67), e4308, doi:10.3791/4308 (2012).
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