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Synthesis of Phase-shift Nanoemulsions with Narrow Size Distributions for Acoustic Droplet Vaporization and Bubble-enhanced Ultrasound-mediated Ablation
'Bu içeriği görüntülemek için JoVE aboneliği gereklidir.' 'Oturum açın veya ücretsiz deneme sürümünü başlatın.'
'Bölümler'
- 00:05'Başlık'
- 01:32Preparation of Phase-shift Nanoemulsion (PSNE)
- 03:55Nanoemulsion Vaporization and Bubble-enhanced Ablation in Hydrogel
- 06:24Results: Vaporizing PSNE Droplets in Hydrogels
- 07:54Conclusion
Phase-shift nanoemulsions (PSNE) can be vaporized using high intensity focused ultrasound to enhance localized heating and improve thermal ablation in tumors. In this report, the preparation of stable PSNE with a narrow size distribution is described. Furthermore, the impact of vaporized PSNE on ultrasound-mediated ablation is demonstrated in tissue-mimicking phantoms.
'Etiketler'
SynthesisPhase-shift NanoemulsionsNarrow Size DistributionsAcoustic Droplet VaporizationBubble-enhanced Ultrasound-mediated AblationHigh-intensity Focused Ultrasound (HIFU)Lipid-coated Perfluorocarbon DropletsLocalized HeatingThermal AblationTumorsVasculatureNanoparticlesFenestrationsPassive AccumulationDroplet Size ControlPreparationStable DropletsSonicatingLiquid PerfluorocarbonExtrusionFiltersPore SizesSize Distribution MeasurementDynamic Light ScatteringPolyacrylamide HydrogelsIn Vitro Experiments
