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Multi-photon Imaging of Tumor Cell Invasion in an Orthotopic Mouse Model of Oral Squamous Cell Carcinoma
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Multi-photon Imaging of Tumor Cell Invasion in an Orthotopic Mouse Model of Oral Squamous Cell Carcinoma

Multi-photon Imaging of Tumor Cell Invasion in an Orthotopic Mouse Model of Oral Squamous Cell Carcinoma

18,702 Views

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12:03 min

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July 25, 2011

DOI:

10.3791/2941-v

DOI:
10.3791/2941-v

•

12:03 min
July 25, 2011

•

20 Views
, , , , ,
1Department of Neurobiology and Anatomy, Program in Cancer Cell Biology,Mary Babb Randolph Cancer Center, West Virginia University, 2Sensory Neuroscience Research Center,West Virginia University , 3Departments of Otolaryngology and Physiology, Center for Neuroscience,West Virginia University

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A comprehensive overview of the techniques involved in generating a mouse model of oral cancer and quantitative monitoring of tumor invasion within the tongue through multi-photon microscopy of labeled cells is presented. This system can serve as a useful platform for the molecular assessment and drug efficacy of anti-invasive compounds.

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Cite this Article

Gatesman Ammer, A., Hayes, K. E., Martin, K. H., Zhang, L., Spirou, G. A., Weed, S. A. Multi-photon Imaging of Tumor Cell Invasion in an Orthotopic Mouse Model of Oral Squamous Cell Carcinoma. J. Vis. Exp. (53), e2941, doi:10.3791/2941 (2011).

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